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Gajate, C., Barasoain, I., Andreu, J.M., and Mollinedo, F.
“Induction of apoptosis in leukemic cells by the reversible microtubule-disrupting agent 2-methoxy-5-(2’,3’,4’-trimethoxyphenyl)-2,4,6-cycloheptatrien-1-one: protection by Bcl-2 and Bcl-XL, and cell cycle arrest.
Cancer Research 60, 2651-2659 (2000).
(Pubmed)
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Martín-Martín, B., Nabokina, S.M., Blasi, J., Lazo, P.A., and Mollinedo, F.
“Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosis.”
Blood 96, 2574-2583 (2000).
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Gajate, C., and Mollinedo, F.
“The antitumor ether lipid ET-18-OCH3 induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells.
Blood 98, 3860-3863 (2001).
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Gajate, C., An, F., and Mollinedo, F.
“Differential cytostatic and apoptotic effects of Ecteinascidin-743 in cancer cells. Transcription-dependent cell cycle arrest and transcription-independent JNK and mitochondrial mediated apoptosis.
Journal of Biological Chemistry 277, 41580-41589 (2002).
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Mollinedo, F., Martín-Martín, B., Calafat, J., Nabokina, S.M., and Lazo, P.A.
“Role of vesicle-associated membrane protein-2, through Q-soluble N-ethylmaleimide-sensitive factor attachment protein receptor/R-soluble N-ethylmaleimide-sensitive factor attachment protein receptor interaction, in the exocytosis of specific and tertiary granules of human neutrophils.
Journal of Immunology 170, 1034-1042 (2003).
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Gajate, C., An, F. and Mollinedo, F.
“Rapid and selective apoptosis in human leukemic cells induced by Aplidine through a Fas/CD95- and mitochondrial-mediated mechanism.
Clinical Cancer Research 9, 1535-1545 (2003).
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Gajate, C., del Canto-Jañez, E., Acuña, A.U., Amat-Guerri, F., Geijo, E., Santos-Beneit, A.M., Veldman, R.J., and Mollinedo, F.
“Intracellular triggering of Fas aggregation and recruitment of apoptotic molecules into Fas-enriched rafts in selective tumor cell apoptosis.
Journal of Experimental Medicine 200, 353-365 (2004).
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Munder, M., Mollinedo, F., Calafat, J., Canchado, J., Gil-Lamaignere, C., Fuentes, J.M., Luckner, C., Doschko, G., Soler, G., Eichmann, K., Müller, F.-M., Ho, A.D., Goerner, M., and Modolell, M.
“Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity.
Blood 105, 2549-2556 (2005).
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Gajate, C., and Mollinedo, F.
“Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis promoting clusters in cancer chemotherapy.
Journal of Biological Chemistry 280, 11641-11647 (2005).
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Zaremberg, V., Gajate, C., Cacharro, L.M., Mollinedo, F., and McMaster, C.R.
“Cytotoxicity of an anti-cancer lysophospholipid through selective modification of lipid raft composition.
Journal of Biological Chemistry 280, 38047-38058 (2005).
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David-Cordonnier, M.-H., Gajate, C., Olmea, O., Laine, W., de la Iglesia-Vicente, J., Perez, C., Cuevas, C., Otero, G., Bailly, C., and Mollinedo, F.
“DNA and Non-DNA Targets in the Mechanism of Action of the Antitumor Drug Trabectedin.
Chemistry & Biology 12, 1201-1210 (2005).
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Nieto-Miguel, T., Gajate, C., and Mollinedo, F.
“Differential targets and subcellular localization of antitumor alkyl-lysophospholipid in leukemic versus solid tumor cells.
Journal of Biological Chemistry. 281, 14833-14840 (2006).
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Mollinedo, F., Calafat, J., Janssen, H., Martín-Martín, B., Canchado, J., Nabokina, S.M., and Gajate, C.
“Combinatorial SNARE complexes modulate the secretion of cytoplasmic granules in human neutrophils.
Journal of Immunology. 177, 2831-2841 (2006).
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Gómez-Gaviro, M., Domínguez-Luis, M., Canchado, J., Calafat, J., Janssen, H., Lara-Pezzi, E., Fourie, A., Tugores, A., Valenzuela-Fernández, A., Mollinedo, F., Sánchez-Madrid, F., and Díaz-González, F.
“Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding.
Journal of Immunology. 178, 8053-8063 (2007).
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Gajate, C., and Mollinedo, F.
“Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts.
Blood 109, 711-719 (2007).
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Nieto-Miguel, T., Fonteriz, R.I., Vay, L., Gajate, C., López-Hernández, S., and Mollinedo, F. “Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cells. Cancer Research 67, 10368-10378 (2007).
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Wang XY., Dakir el H., Naizhen X., Jensen-Taubman SM., DeMayo FJ., Linnoila RI. “Achaete-scute homolog-1 linked to remodeling and preneoplasia of pulmonary epithelium. Laboratory Investigation. 87(6):527-539 (2007).
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Nieto-Miguel, T., Gajate, C., González-Camacho, F., and Mollinedo, F.
“Proapoptotic role of Hsp90 by its interaction with c-Jun N-terminal kinase in lipid rafts in edelfosine-mediated antileukemic therapy.
Oncogene 27, 1779-1787 (2008).
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Mitsiades, C.S., Ocio, E.M., Pandiella, A., Maiso, P., Gajate, C., Garayoa, M., Vilanova, D., Montero, J.C., Mitsiades, N., McMullan, C.J., Munshi, N.C., Hideshima, T., Chauhan, D., Aviles, P., Otero, G., Faircloth, G., Mateos, M.V., Richardson, P.G., Mollinedo, F., San-Miguel, J.F., and Anderson, K.C.
“Aplidin, a marine compound with strong anti-myeloma activity.
Cancer Research 68, 5216-5225 (2008).
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Herrero-Turrión, M.J., Calafat, J., Janssen, H., Fukuda, M., and Mollinedo, F.
“Rab27a regulates exocytosis of tertiary and specific granules in human neutrophils.
Journal of Immunology 181, 3793-803 (2008).
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Dakir EL., Feigenbaum L., Linnoila RI. “Constitutive expression of human keratin 14 gene in mouse lung induces premalignant lesions and squamous differentiation.
Carcinogenesis. 29(12): 2377-2384 (2008).
(Pubmed)
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Dr. Javier De Las Rivas
Dr. Faustino Mollinedo